2022 the 4th International Conference on Modeling, Simulation, Optimization and Algorithm[ICMSOA 2022], 12 November, 2022

ABOUT ICMSOA2022Organized by Yaseen Academy, 2022 The 2nd International Conference on Modeling, Simulation, Optimization and Algorithm (ICMSOA 2022), which was planned to be held during 11-13 November, 2022 at Sanya, Hainan Province, China. Due to the travel restrictions caused by covid, the participants joined the conference online via Tencent Meeting at 12 November, 2022. The Conference looks for significant contributions to related fields of Modeling, Simulation, Optimization and Algorithm. The aim of the conference is to provide a platform to the researchers and practitioners from both academia as well as industry to meet and share cutting-edge development in the field.CALL FOR PAPERSPlease make sure your submission is in related areas of the following general topics. The topics include, but are not limited to:Simulation modeling theory and technology, Computational modeling and simulation, System modeling and simulation, Device/VLSI modeling and simulation, Control theory and applications, Military Technology Simulation, Aerospace technology simulation, Information engineering simulation, Energy Engineering Simulation, Manufacturing Simulation, Intelligent engineering simulation, Building engineering simulation, Electromagnetic field simulation, Material engineering simulation, Visual simulation, Fluid mechanics engineering simulation, Manufacturing simulation technology, Simulation architecture, Simulation software platform and Intelligent Optimization Algorithm, Dynamic Programming, Ant Colony Optimization, Genetic Algorithm, Simulated Annealing Algorithm, Tabu Search Algorithm, Ant Colony System Algorithm, Hybrid Optimization Algorithm in other related areas.The conference was begun at 10:00am, ended at 17:30am, 12 November, 2022. There were 77 participants in total, 2 keynote speakers and 17 invited oral speakers, Assoc. Prof. Jinyang Xu from Shanghai Jiaotong Univeristy in China and Dr. Victor Koledov from Innowledgement GmbH in Germany delivered their keynote speeches, each speech cost about 50 minutes, including the questions&discussion time.On behalf of the conference organizing committee, we'd like to acknowledge the unstinting support from our colleagues at Yaseen Academy, all Technical Program Members, speakers, reviewers, and all the participants for their sincere support.Conference Organizing CommitteeICMSOA 2022List of Conference General Chair, Program Chair, Conference Committee Chair Members, International Technical Committee Members, International Reviewers are available in this Pdf.

Theory and Simulation of Multipurpose Antenna for Detection and Degrading of Viruses in Times of Pandemic

This paper present a theoretical model that aims to minimize the capabilities of viruses in public places through engineered electromagnetic fields. Thus, the modeling of antenna based at the infinitesimal dipole is used. In addition fields and directivity at the far field region are calculated. This proposal empathizes the fact that the radiated energy will affect the spike protein of viruses. In this manner the functionality of virus as to produce infection would be minimized. Simulations of the radiate electric field are presented. © 2022 IEEE.

Microwaves can kill malaria parasites non-thermally.

Malaria, which infected more than 240 million people and killed around six hundred thousand only in 2021, has reclaimed territory after the SARS-CoV-2 pandemic. Together with parasite resistance and a not-yet-optimal vaccine, the need for new approaches has become critical. While earlier, limited, studies have suggested that malaria parasites are affected by electromagnetic energy, the outcomes of this affectation vary and there has not been a study that looks into the mechanism of action behind these responses. In this study, through development and implementation of custom applicators for in vitro experimentation, conditions were generated in which microwave energy (MW) killed more than 90% of the parasites, not by a thermal effect but via a MW energy-induced programmed cell death that does not seem to affect mammalian cell lines. Transmission electron microscopy points to the involvement of the haemozoin-containing food vacuole, which becomes destroyed; while several other experimental approaches demonstrate the involvement of calcium signaling pathways in the resulting effects of exposure to MW. Furthermore, parasites were protected from the effects of MW by calcium channel blockers calmodulin and phosphoinositol. The findings presented here offer a molecular insight into the elusive interactions of oscillating electromagnetic fields with P. falciparum, prove that they are not related to temperature, and present an alternative technology to combat this devastating disease.

Magnetic mitohormesis: A non-invasive therapy for inflammatory disorders?

An organism's survival depends on its ability to adapt to stress. Mitochondria are the cellular integrators of environmental stressors that ultimately translate their responses at the organismal level, and are thus central to the process whereby organisms adapt to their respective environments. Mitochondria produce molecular energy via oxidative phosphorylation that then allows cells to biosynthetically respond and adapt to changes in their environment. Reactive oxygen species (ROS) are by-products of oxidative phosphorylation that can be either beneficial or damaging, depending on the context;ROS are hence both the conveyors of environmental stress as well as cellular "adaptogens”. Mitohormesis refers to the process whereby low levels of oxidative stress spur survival adaptations, whereas excessive levels stymie survival. Low energy and frequency pulsing electromagnetic fields have been recently shown capable of stimulating mitochondrial respiration and ROS production and instilling mitohormetic survival adaptations, similarly to, yet independently of, exercise, opening avenues for the future development of Magnetic Mitohormetic interventions for the improvement of human health. This viewpoint explores the possibilities and nuances of magnetic-based therapies as a form of clinical intervention to non-invasively activate magnetic mitohormesis for the management of chronic diseases. © 2023 Centro Regional de Invest. Cientif. y Tecn.. All rights reserved.

Content, Connection and Careers: Kit-Based Learning and Virtual University Connections (Evaluation)

Science kits have been a staple of learning for some time, but in the era of COVID-19 at-home science kits took specific prominence in educational initiatives. In this paper, we delineate how kit-based education can be paired with virtual connection technology to enhance postsecondary and career exploration. The “Content, Connection and Careers” kit-based program has been developed to enable youth to explore electrical engineering principles while connecting virtually with university students to discuss engineering courses and careers. When assembled and wired up, the kit components become linear motors that use a magnetic force to pull a bolt into a pipe when youth press a button. This follows the same working principles as a doorbell or solenoid. These kits are supported by virtual learning sessions where youth connect with university students and faculty to fully understand the educational content, connect to peers and caring adults to share their learning, and explore careers that use electrical engineering skills. To investigate the effectiveness of the program, surveys were distributed to participants to understand whether the kits were simple enough for independent learning but robust enough to encourage additional self-exploration of more difficult topics with the aid of expert scientists and other adult role models. Additionally, youth were asked if the connections made with university faculty and students was beneficial in their thinking of postsecondary options and college engagement. Over 60 elementary and middle-school aged youth participated in the project. Over 80 percent of survey respondents self-reported improved knowledge of how an electromagnetic field works and how to build a simple electromagnet. Other results showed an increased understanding of engineering careers and courses required to study electric engineering in college. Before their experience in the project, very few of the young people had ever talked to university faculty or university students about their areas of research or their journey into the fields of science, technology, engineering, and math (STEM). This connection was described in the surveys as what the youth liked best about the project. © American Society for Engineering Education, 2022.

Continuous EMF Monitoring as an Emergency and Disaster Detection Tool

A number of applications founded on electromagnetic field (EMF) has increased, since wireless personal communication devices are used by a large number of people. Simultaneously, the controversy about adverse health effects of EMF exposure is in a focus of the public debate. Thus, there are constant demands for comprehensive investigation and monitoring of existing exposure to EMF. In last decade, the wireless sensors networks emerged as an innovative solution for EMF monitoring in the environment. The newest established is Serbian EMF RATEL network that performs continuous wideband monitoring, counting contribution of all active EMF sources, in particular frequency range and in the vicinity of observed location. Besides the monitoring for the health protection purposes, this network can be used as an emergency and disaster detection tool, as demonstrated in a case study of COVID-19 presence in campus of the University of Novi Sad. In this paper, technical details of the Serbian EMF RATEL monitoring network are presented, along with monitoring results from two campus locations, which clearly indicate some significant changes in the EMF level. © 2022 IEEE.

AN INTEGRATED RT-LAMP AND CRISPR ASSAY FOR NUCLEIC ACID DETECTION IN A SINGLE MICROFLUIDIC CHIP

We will present a microfluidic assay to detect SARS-CoV-2 RNA from nasopharyngeal swab samples. Our method leverages isotachophoresis (ITP) to integrate sample preparation, RT-LAMP, and CRISPR-based nucleic acid detection in an automatable chip. For the first time, we use ITP to purify, pre-concentrate and isothermally amplify target nucleic acids into a ~1 µL reaction volume on-chip. The device then transitions LAMP amplicons into an on-chip zone containing Cas12-gRNA complexes and reporter molecules to measure target-activated CRISPR activity. We will use our method to automatically detect COVID-19 from nasopharyngeal swab samples. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

Causality of COVID-19 on EMF Radiation in Campus Area of University of Novi Sad

The mobile telephony became one of the worldwide most important technology, allowing wireless communication at any moment and virtually at any place. It is based on electromagnetic field (EMF) radiation from its network base stations, which inevitable cause EMF expansion in surrounding. However, the new base stations are followed by strong controversy, increasing concerns of the public, regarding potentially dangerous health effects of the EMFs. Thus, there is a constant demand for overall investigation and supervision of existing EMF exposure. In last decade, the wireless sensors networks emerged as an innovative solution for effective monitoring of EMFs in the environment. The latest established is the Serbian EMF RATEL network, which offers a sophisticated approach of telecommunication service-based EMF monitoring. This network performs wideband monitoring, taking into account the contribution of all active EMF sources in the vicinity of specific location. In this paper, the new role of the EMF RATEL system is considered, analyzing it as a smart solution for an emergency management. The perceptible causality of the COVID-19 on EMF radiation in campus area of University of Novi Sad is investigated, regarding the extensive activities of students in this part of the city of Novi Sad. © 2022, ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering.

Clinical validation of SERS metasurface SARS-CoV-2 biosensor

The real-Time polymerase chain reaction (RT-PCR) analysis using nasal swab samples is the gold standard approach for COVID-19 diagnosis. However, due to the high false-negative rate at lower viral loads and complex test procedure, PCR is not suitable for fast mass screening. Therefore, the need for a highly sensitive and rapid detection system based on easily collected fluids such as saliva during the pandemic has emerged. In this study, we present a surface-enhanced Raman spectroscopy (SERS) metasurface optimized with genetic algorithm (GA) to detect SARS-CoV-2 directly using unprocessed saliva samples. During the GA optimization, the electromagnetic field profiles were used to calculate the field enhancement of each structure and the fitness values to determine the performance of the generated substrates. The obtained design was fabricated using electron beam lithography, and the simulation results were compared with the test results using methylene blue fluorescence dye. After the performance of the system was validated, the SERS substrate was tested with inactivated SARS-CoV-2 virus for virus detection, viral load analysis, cross-reactivity, and variant detection using machine learning models. After the inactivated virus tests are completed, with 36 PCR positive and 33 negative clinical samples, we were able to detect the SARS-CoV-2 positive samples from Raman spectra with 95.2% sensitivity and specificity. © COPYRIGHT SPIE. Downloading of the is permitted for personal use only.

Research of Electromagnetic Field Enhancement of Surface Plasmon Resonant Mode in Metal Nanosphere-Nanodisc Structure

Surface plasmon has a history of more than one hundred years since its birth and has been a brand new discipline-plasmonics. Localized surface plasmon in metal nanostructures can gain very strong near-surface electric field enhancement and has been applied to many types researches successfully. However, there is relatively less study of the interaction between localized surface plasmon and magnetic field in incident light. This paper calculates the near-surface electromagnetic field enhancement of metal nanosphere-nanodisc gap based on the previous achievement. This paper shows that under the excitation of the single tightly radially polarized optical beam, the metal nanodisc can produce localized surface plasmon breathing mode and electric dipole moment mode, which give rise to the longitudinal electric field enhancement at the nanodisc center. And then, because of the resonance interaction of the metal nanodisc and localized surface plasmon electric dipolar moment of the metal nanosphere, a gap mode of localized surface plasmon resonance with efficient longitudinal electric field enhancement can be produced. Through carrying out the numerical simulation, this paper demonstrates that the near-surface longitudinal electric field of metal nanostructure gap mode can obtain 250 times electrical field enhancement relative to the valid transverse electrical field that is used to excite the breathing mode, and the enhancement factor of near-surface magnetic field could be 170. In order to present more clearly the character of the spectrum and the near-surface electromagnetic field distribution of this new metal nanostructure, the near-surface electromagnetic field distribution and the resonant wavelengths of this new metal nanostructure are also studied. The calculation results show that the proposed metal nanosphere-nanodisc nanostructure owns an obvious advantage on the local near-surface electromagnetic field enhancement and a relatively large frequency spectrum. Due to the electromagnetic field enhancement advantage of the metal nanostructure proposed by this paper, the future is not without hope that the results here could be applied to more and more researches, especially biomedicine, and provide a bit of reference in order to fight for novel coronavirus. © 2022, Peking University Press. All right reserved.

Predictive Theory of Covid-19 infections at European countries through Bessel functions: Past and present

The data of infections by Covid-19 is modeled through the integer-order Bessel functions that have been parametrized in according to the morphology of data. In particular, the modeling is focused on official data belonging to UK, Germany, Italy and Netherlands. The free parameters of model have been coherently linked to data. Interestingly, it was seen that a”silent period” with the lowest cases of infections play a relevant role for new pandemics as well as the apparition of new strains, such as the most recent”delta-variant”. © 2021 IEEE.

Evaluation of a Smectite Adsorption-Based Electrostatic System to Decontaminate F− Rich Thermal Waters

Several studies have shown the presence of fluoride levels much higher than the 1.5 mg/L threshold concentration recommended by WHO in the spring waters and wells of the Ethiopian Rift Valley. Available defluoridation techniques can be costly, present complicated technical aspects, and show limited effectiveness. Therefore, it is necessary to devise innovative, sustainable, and effective solutions. This study proposes an alternative method of intervention to the known techniques for removing fluoride from water, particularly suitable for smaller rural communities. In particular, in this work, the possibility to use electromagnetic fields as a physical method for removing the excess fluoride was investigated. The study was carried out by developing a multiphysics model used for studying and envisaging the design of a device. In this framework, the combination of this approach with the use of highly reactive smectite clay was numerically studied. The results obtained, although preliminary, indicate that the proposed system could significantly impoverish the waters of the Rift Valley from fluoride, with the consequence of obtaining a resource suitable for human consumption, in particular for rural communities. However, further theoretical investigations and experimental phases will be necessary to achieve the desired results.

Therapeutic application of light and electromagnetic fields to reduce hyper-inflammation triggered by COVID-19.

COVID-19 - related morbidity is associated with exaggerated inflammation and cytokine production in the lungs, leading to acute respiratory failure. The cellular mechanisms underlying these so-called 'cytokine storms' are regulated through the Toll-like receptor 4 (TLR4) signaling pathway and by ROS (Reactive Oxygen Species). Both light (Photobiomodulation) and magnetic fields (e.g., Pulsed Electro Magnetic Field) stimulation are noninvasive therapies known to confer anti-inflammatory effects and regulate ROS signaling pathways. Here we show that daily exposure to two 10-minute intervals of moderate intensity infra-red light significantly lowered the inflammatory response induced via the TLR4 receptor signaling pathway in human cell cultures. Anti-inflammatory effects were likewise achieved by electromagnetic field exposure of cells to daily 10-minute intervals of either Pulsed Electromagnetic Fields (PEMF), or to Low-Level static magnetic fields. Because current illumination and electromagnetic field therapies have no known side effects, and are already approved for some medical uses, we have here developed protocols for verification in clinical trials of COVID-19 infection. These treatments are affordable, simple to implement, and may help to resolve the acute respiratory distress of COVID-19 patients both in the home and in the hospital.

Therapeutic Nuclear Magnetic Resonance affects the core clock mechanism and associated Hypoxia-inducible factor-1.

The influence of low intensity electromagnetic fields on circadian clocks of cells and tissues has gained increasing scientific interest, either as a therapeutic tool or as a potential environmental hazard. Nuclear Magnetic Resonance (NMR) refers to the property of certain atomic nuclei to absorb the energy of radio waves under a corresponding magnetic field. NMR forms the basis for Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy and, in a low-intensity form, for NMR therapy (tNMR). Since the circadian clock is bi-directionally intertwined with hypoxic signaling in vertebrates and mammals, we hypothesized that low intensity electromagnetic fields, such as tNMR, might not only affect circadian clocks but also Hypoxia-Inducible Factor-1α (HIF-1α). As master regulator of the hypoxic signaling pathway, HIF-1α is known to dampen the circadian amplitude under reduced oxygen availability, while the hypoxic response of cells and organisms, itself, is tightly clock controlled. In a first experiment, we investigated if tNMR is able to act as Zeitgeber for the core clock mechanism of unsynchronized zebrafish and mouse fibroblast cells, using direct light irradiation and treatment with the glucocorticoid Dexamethasone as references. tNMR significantly affected the cell autonomous clocks of unsynchronized mouse fibroblast cells NIH3-T3, but did not act as a Zeitgeber. Similar to light irradiation and in contrast to treatment with Dexamethasone, tNMR did not synchronize expression profiles of murine clock genes. However, irradiation with tNMR as well as light significantly altered mRNA and protein expression levels of Cryptochrome1, Cryptochrome2 and Clock1 for more than 24 h. Changes in mRNA and protein after different treatment durations, namely 6 and 12 h, appeared to be nonlinear. A nonlinear dose-response relationship is known as hallmark of electromagnetic field induced effects on biological systems. The most prominent alterations were detected in murine HIF-1α protein, again in a nonlinear dose-response. In contrast to murine cells, zebrafish fibroblasts did not respond to tNMR at all. Light, a potent Zeitgeber for the peripheral clocks of fish, led to the expected synchronized clock gene oscillations of high amplitude, as did Dexamethasone. Hence, we conclude, mammalian peripheral clocks are more susceptible to tNMR than the direct light entrainable fish fibroblasts. Although light and tNMR did not act as Zeitgebers for the circadian clocks of unsynchronized murine cells, the significant observed effects might indicate downstream cell-physiological ramifications, which are worth future investigation. However, beside the effects tNMR exerts on the core clock mechanism of mammalian cells, the technology might be the first non-pharmacological approach to modify HIF-1α protein in cells and tissues. HIF-1α and the associated circadian clock play key roles in diseases with underlying ischemic background, such as infarct, stroke, and cancer and, also infectious diseases, such as Covid-19. Hence, low intensity magnetic fields such as tNMR might be of significant medical interest.

What sunspots are whispering about covid-19?

Several studies point to the antimicrobial effects of ELF electromagnetic fields. Such fields have accompanied life from the very beginning, and it is possible that they played a significant role in its emergence and evolution. However, the literature on the biological effects of ELF electromagnetic fields is controversial, and we still lack an understanding of the complex mechanisms that make such effects, observed in many experiments, possible. The Covid-19 pandemic has shown how fragile we are in the face of powerful processes operating in the biosphere. We believe that understanding the role of ELF electromagnetic fields in regulating the biosphere is important in our fight against Covid-19, and research in this direction should be intensified.